Licensing of fluoxetine, venlafaxine, nefazodone, and paroxetine. The researchers obtained data on all the clinical trials submitted to the FDA for the Whether the baseline severity of depression affects antidepressant efficacy. Groups of patient, so in the meta-analysis in this paper, the researchers investigated However, average improvement scores may obscure beneficial effects between different Placebo, whereas NICE has defined a significant clinical benefit for antidepressants asĪ drug–placebo difference in the improvement of the HRSD score of 3 points. On average, the SSRIs improved the HRSD score of patients by 1.8 points more than the
Meta-analysis of the published and unpublished trials on SSRIs submitted to the FDAĭuring licensing has indicated that these drugs have only a marginal clinical benefit. Statistical method for combining the results of many studies. Information about the new drug's effectiveness but additional information can be gainedīy combining the results of all the trials in a “meta-analysis,” a Placebo, a dummy tablet that contains no drug. Trials that compare its ability to improve the HRSD scores of patients with that of a SSRIs for the treatment of depression, some doubts remain about their clinical efficacy.īefore an antidepressant is approved for use in patients, it must undergo clinical Health and Clinical Excellence (NICE), and other licensing authorities have approved Newest antidepressants and include fluoxetine, venlafaxine, nefazodone, andĪlthough the US Food and Drug Administration (FDA), the UK National Institute for “selective serotonin reuptake inhibitors” (SSRIs). Hypothesized to normalize the brain chemicals that affect mood. Is usually a combination of psychotherapy and an antidepressant drug, which is For more severe depression, current treatment Therapy (for example, cognitive–behavioral therapy helps people to change Mild depression is often treated with psychotherapy or talk Question are given a score and a total score for the questionnaire of more than 18 The severity of depression using the “Hamilton Rating Scale ofĭepression” (HRSD), a 17–21 item questionnaire. Life, making them feel hopeless, worthless, unmotivated, even suicidal. It affects one in six people at some time during their Depression is a serious medical illness caused by imbalances in the brainĬhemicals that regulate mood.
But for some people-those withĭepression-these sad feelings last for months or years and interfere withĭaily life. National Institute for Clinical Excellence Įveryone feels miserable occasionally. Hamilton Rating Scale of Depression LOCF, Of the Creative Commons Attribution License, which permits unrestricted use, distribution,Īnd reproduction in any medium, provided the original author and source are credited.įunding: The authors received no specific funding for this study.Ĭompeting interests: IK has received consulting fees from Squibb and Pfizer. This is an open-access article distributed under the terms Received: JanuAccepted: JanuPublished: February 26, 2008Ĭopyright: © 2008 Kirsch et al. PLoS Med 5(2):Īcademic Editor: Phillipa Hay, University of Western Sydney, Australia More meanings of this word and English-Russian, Russian-English translations for the word «FOOD» in dictionaries.Citation: Kirsch I, Deacon BJ, Huedo-Medina TB, Scoboria A, Moore TJ, Johnson BT (2008) Initial Severity and Antidepressant Benefits: A Meta-Analysis of Data Submitted to the Food and Drug Administration.